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KHS101 hydrochloride

CAT: 0804-HY-10996A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10996A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3) .
CAS Number
1784282-12-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/KHS101_hydrochloride.html
Purity
99.65
Solubility
DMSO : 160 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.CC(CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1)C
Molecular Formula
C18H22ClN5S
Molecular Weight
375.92
Precautions
H315, H319, H320
References & Citations
[1]Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107 (38) :16542-7.|[2]Polson ES, et al. KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice. Sci Transl Med. 2018 Aug 15;10 (454) . pii: eaar2718.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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