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Cyclopropenone probe 1

CAT: 0804-HY-132913Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-132913Size:1 Each
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Description
Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site. Cyclopropenone probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2771119-22-1
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclopropenone-probe-1.html
Solubility
10 mM in DMSO
Smiles
C#CCOC1=CC=C(C=C1)C2=CC2=O
Molecular Formula
C12H8O2
Molecular Weight
184.19
References & Citations
[1]Fan Y, et al. Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery". J Med Chem. 2021 Nov 11;64 (21) :15582-15592.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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