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NLRP3-IN-4

CAT: 0804-HY-132892Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-132892Size:1 Each
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Description
NLRP3-IN-4 is potent and orally active NLRP3 inflammasome inhibitor with inflammatory activity for colitis.
CAS Number
2758595-77-4
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-4.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=CC(/C=C/C2=CC=C(C=C2)NC(C3CC3)=O)=C1/C=C/[N+]([O-])=O
Molecular Formula
C22H22N2O5
Molecular Weight
394.42
References & Citations
[1]Chen LZ, et al. Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. J Med Chem. 2021 Sep 23;64 (18) :13633-13657.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3

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