NLRP3-IN-34

NLRP3-IN-34

• CAS Number: 1392502-55-4
• UNSPSC Description: NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC50 is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis[1].
• Target Antigen: NOD-like Receptor (NLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-34.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=COC2=C1C(C(C3=C2C=CC4=C3C(CCC4(C)C)OC(C5=C(C=CC=C5)O)=O)=O)=O
• Molecular Weight: 430.45
• References & Citations: [1]Chen H, et al., Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 May 15;104:129725.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported