NLRP3-IN-17
CAT:
804-HY-153261-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NLRP3-IN-17
- CAS Number: 2254432-75-0
- UNSPSC Description: NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research[1].
- Target Antigen: NOD-like Receptor (NLR)
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/nlrp3-in-17.html
- Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 80°C)
- Smiles: N#CN=S(NC(NC1=C(CCC2)C2=CC3=C1CCC3)=O)(C4=CC=C(C)C=C4)=O
- Molecular Weight: 394.49
- References & Citations: [1]Sameer Agarwal, et al. Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2020 Feb 27;11(4):414-418.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported