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DAPM

CAT: 0804-HY-131923-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131923-01Size:1 mg
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Description
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells[1].
CAS Number
208255-51-0
UNSPSC
12352209
Target
Notch
Type
Peptides
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dapm.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(F)=CC(CC(N[C@@H](C)C(N[C@@H](C2=CC=CC=C2)C(OC)=O)=O)=O)=C1
Molecular Formula
C20H20F2N2O4
Molecular Weight
390.38
References & Citations
[1]Miyamoto S, et al. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis. 2013 Oct;34 (10) :2415-23.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

gamma-Secretase Inhibitor XVI
CAS Number208255-51-0
PubChem CID10452973
IUPAC Namemethyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Molecular FormulaC20H20F2N2O4
Molecular Weight390.4
XLogP2.7
Topological Polar Surface Area84.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count28
Formal Charge0
Complexity544
SMILES
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC)NC(=O)CC2=CC(=CC(=C2)F)F
InChI
InChI=1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
InChIKey
XAPDRNSTUYCSQC-SGTLLEGYSA-N
Chemical Structure
2D Structure
2D structure of gamma-Secretase Inhibitor XVI
CAS: 208255-51-0
CID: 10452973
Formula: C20H20F2N2O4
MW: 390.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.4
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass390.13911345
Monoisotopic Mass390.13911345
Topological Polar Surface Area84.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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