DAPM

• Description :

  DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells[1].

• CAS Number :

  [208255-51-0]

• UNSPSC :

  12352209

• Target :

  Notch

• Type :

  Peptides

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dapm.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC(F)=CC(CC(N[C@@H](C)C(N[C@@H](C2=CC=CC=C2)C(OC)=O)=O)=O)=C1

• Molecular Formula :

  C20H20F2N2O4

• Molecular Weight :

  390.38

• References & Citations :

  [1]Miyamoto S, et al. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis. 2013 Oct;34 (10) :2415-23.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported