Products for Research Use Only
RegisterLogin

DAPM

CAT: 0931-T86161-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T86161-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
208255-51-0
Target
Gamma-secretase
Related Pathways
Stem Cells, Proteases/Proteasome, Neuroscience
Purity
0.9976
Bioactivity
DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects, inhibits cell proliferation and induces the expression of Krüppel-like Factor 4 (KLF4) and p21 in human colon cancer cells, inhibits Notch signaling, and can be used in the study of renal tubular adenomas.
Smiles
[C@@H](NC([C@@H](NC(CC1=CC(F)=CC(F)=C1)=O)C)=O)(C(OC)=O)C2=CC=CC=C2
Molecular Formula
C20H20F2N2O4
Molecular Weight
390.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

gamma-Secretase Inhibitor XVI
CAS Number208255-51-0
PubChem CID10452973
IUPAC Namemethyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Molecular FormulaC20H20F2N2O4
Molecular Weight390.4
XLogP2.7
Topological Polar Surface Area84.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count28
Formal Charge0
Complexity544
SMILES
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC)NC(=O)CC2=CC(=CC(=C2)F)F
InChI
InChI=1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
InChIKey
XAPDRNSTUYCSQC-SGTLLEGYSA-N
Chemical Structure
2D Structure
2D structure of gamma-Secretase Inhibitor XVI
CAS: 208255-51-0
CID: 10452973
Formula: C20H20F2N2O4
MW: 390.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.4
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass390.13911345
Monoisotopic Mass390.13911345
Topological Polar Surface Area84.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T207665-01DAPI
T6202-01DAPT
T86160-01DAPI dilactate
T19827-01DAPI Dihydrochloride
T209246-01DapE-IN-1
T25288-01DapL-IN-1
T77611-01DAPK-IN-2
T39967Br-DAPI
T17004-01TC-DAPK 6
TP2205DAPK Substrate Peptide

Alternative Products

CatalogName
BUP01789-01DAPM
HY-176516DAPM-1 (acetate)
GTR19264052-01DAPM-1 acetate

Popular Products