FM-479

• Description:

  FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

• UNSPSC:

  12352005

• Target:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fm-479.html

• Purity:

  99.2

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N (C) C) /C (C#N) =C/C1=CC=C (C2=NC3=CN=C (N (C) C=C4) C4=C3N2C5CCCCC5) O1

• Molecular Formula:

  C25H26N6O2

• Molecular Weight:

  442.51

• References & Citations:

  [1]https://www.thesgc.org/chemical-probes/FM-381

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK3

• CAS Number:

  2226521-64-6