FM-479

• UNSPSC Description:

  FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of?JAK3?targeting the unique Cys909. FM-381 has an?IC50?of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

• Target Antigen:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fm-479.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)O1

• Molecular Weight:

  442.51

• References & Citations:

  [1]https://www.thesgc.org/chemical-probes/FM-381

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2226521-64-6