G-479

• UNSPSC Description:

  G-479 is the inhibitor for MEK and hERG channel (IC50=14 μM). G-479 inhibits the proliferation of HCT-116 and A375 with IC50 of 0.049 μM and 0.004 μM. G-479 exhibits good metabolic stability in liver microsomes and good pharmacokinetic characteristics in rats[1].

• Target Antigen:

  MEK; Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;Membrane Transporter/Ion Channel

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/g-479.html

• Smiles:

  O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=N1)=CN=C3)NOC[C@H](O)CO

• Molecular Weight:

  487.22

• References & Citations:

  [1]Robarge KD, et al., Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4714-4723.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1168092-22-5