FM-381

• Description:

  FM-381, a chemical probe, is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H332, H335

• Target:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/FM381.html

• Purity:

  99.58

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles:

  CN (C (/C (C#N) =C/C1=CC=C (C2=NC3=CN=C (NC=C4) C4=C3N2C5CCCCC5) O1) =O) C

• Molecular Formula:

  C24H24N6O2

• Molecular Weight:

  428.49

• Precautions:

  H302, H315, H319, H332, H335

• References & Citations:

  [1]Forster M, et al. Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol. 2016 Nov 17;23 (11) :1335-1340.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK3

• CAS Number:

  2226521-65-7