FM-381

• Description :

  FM-381, a chemical probe, is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively[1].

• CAS Number :

  [2226521-65-7]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H332, H335

• Target :

  JAK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/FM381.html

• Purity :

  99.58

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles :

  CN(C(/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)O1)=O)C

• Molecular Formula :

  C24H24N6O2

• Molecular Weight :

  428.49

• Precautions :

  H302, H315, H319, H332, H335

• References & Citations :

  [1]Forster M, et al. Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol. 2016 Nov 17;23 (11) :1335-1340.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  JAK3