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DPNB-ABT594

CAT: 0804-HY-131001Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131001Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPNB-ABT594 is a nitrobenzyl-caged ABT594 and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR-mediated Ca2+ signalling in the MHb[1].
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dpnb-abt594.html
Solubility
10 mM in DMSO
Smiles
ClC1=NC=C(OC[C@@H]2N(C(C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O)C)CC2)C=C1
Molecular Formula
C31H46ClN3O11
Molecular Weight
672.16
References & Citations
[1]Stefan Passlick, et al. Optical Probing of Acetylcholine Receptors on Neurons in the Medial Habenula With a Novel Caged Nicotine Drug Analogue.J Physiol. 2018 Nov;596 (22) :5307-5318.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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