DPN

• Description :

  DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2].

• CAS Number :

  [1428-67-7]

• Product Name Alternative :

  Diarylpropionitrile

• UNSPSC :

  12352005

• Hazard Statement :

  H319, H400

• Target :

  Apoptosis; Autophagy; Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Vitamin D Related/Nuclear Receptor

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/DPN.html

• Purity :

  99.66

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1

• Molecular Formula :

  C15H13NO2

• Molecular Weight :

  239.27

• Precautions :

  H319, H400

• References & Citations :

  [1]Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9.|[2]Meyers, M. J., et al. Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues. Journal of Medicinal Chemistry, 2001. 44 (24), 4230–4251.|[3]Fuzhong Yang, et al. Physiological dosages of estradiol and diarylpropionitrile decrease depressive behavior and increase tryptophan hydroxylase expression in the dorsal raphe nucleus of rats subjected to the forced swim test. Neuroreport. 2019 Jan 16;30 (2) :66-70.|[4]Sherry A. Said, et al. Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice. GeroScience. 2018 Aug; 40 (4) : 393–403.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERβ