MAK683-CH2CH2COOH

• Description :

  MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) . MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) [1].

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase; Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mak683-ch2ch2cooh.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(O)=O)C=C4)C5=NN=CN35

• Molecular Formula :

  C23H21FN6O3

• Molecular Weight :

  448.45

• References & Citations :

  [1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456 (19) 30362-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2639882-68-9]