Ald-CH2-PEG3-azide

Ald-CH2-PEG3-azide

• CAS Number: 1002342-83-7
• UNSPSC Description: Ald-CH2-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ald-CH2-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Ald-CH2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ald-ch2-peg3-azide.html
• Solubility: 10 mM in DMSO
• Smiles: O=CCOCCOCCOCCN=[N+]=[N-]
• Molecular Weight: 217.22
• References & Citations: [1]Harold L. Kohn , et al. Acylhydrazone-based cleavable linkers. WO2010014236A2.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported