FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2

• UNSPSC Description:

  FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 is a linker of AUTAC4. AUTAC4 contains an p-fluorobenzylguanine (FBnG) and a phenylindole moiety, which can induce K63-linked polyubiquitination and degradation of mitochondria in HeLa cells[1].

• Target Antigen:

  AUTACs

• Type:

  Reference compound

• Related Pathways:

  Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fbng-cys-acetamide-ch2-peg3-ch2-ch2-ch2-nh2.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  NCCCOCCOCCOCCCNC([C@H](CSC1=NC2=C(N=C(N)NC2=O)N1CC3=CC=C(F)C=C3)NC(C)=O)=O

• Molecular Weight:

  622.71

• References & Citations:

  [1]Takahashi D, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2241669-84-9