TCO-PEG3-CH2-aldehyde

TCO-PEG3-CH2-aldehyde

• UNSPSC Description: TCO-PEG3-CH2-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG3-CH2-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tco-peg3-ch2-aldehyde.html
• Solubility: 10 mM in DMSO
• Smiles: O=CCOCCOCCOCCNC(OC1CC/C=C/CCC1)=O
• Molecular Weight: 343.42
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported