Pimozide-d4

CAT: 0804-HY-12987SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12987SSize:1 mg
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Description
Pimozide-d4 is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3].
CAS Number
[1803193-57-8]
Product Name Alternative
R6238-d4
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor; Dopamine Receptor; STAT
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; JAK/STAT Signaling; Neuronal Signaling; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Neurological Disease
Purity
99.2
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC=CC=C2N1C3CCN(CCCC(C4=CC=C(F)C=C4)C5=C([2H])C([2H])=C(F)C([2H])=C5[2H])CC3
Molecular Formula
C28H25D4F2N3O
Molecular Weight
465.57
Precautions
H302
References & Citations
[1]Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256 (2) :141-7.|[2]Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9 (8) :3853-3866. eCollection 2017.|[3]Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117 (12) : 3421-3429.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 4
Isoform
STAT3; STAT5

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