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Pimozide

CAT: 0804-HY-12987-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12987-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
CAS Number
2062-78-4
Product Name Alternative
R6238
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Dopamine Receptor; Parasite; STAT
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; JAK/STAT Signaling; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Pimozide.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2N1C3CCN(CCCC(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3
Molecular Formula
C28H29F2N3O
Molecular Weight
461.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256 (2) :141-7.|[2]Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9 (8) :3853-3866. eCollection 2017.|[3]Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117 (12) : 3421-3429.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
STAT3; STAT5

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MBS3842300-01Pimozide
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TRC-D230005-500MGDehydro Pimozide
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