Pimozide (Standard)

• Description:

  Pimozide (Standard) is the analytical standard of Pimozide. This product is intended for research and analytical applications. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

• Product Name Alternative:

  R6238 (Standard)

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H361

• Target:

  Adrenergic Receptor; Dopamine Receptor; Parasite; Reference Standards; STAT

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; GPCR/G Protein; JAK/STAT Signaling; Neuronal Signaling; Others; Stem Cell/Wnt

• Field of Research:

  Cancer; Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/pimozide-standard.html

• Purity:

  99.81

• Smiles:

  O=C1NC2=CC=CC=C2N1C3CCN (CCCC (C4=CC=C (F) C=C4) C5=CC=C (F) C=C5) CC3

• Molecular Formula:

  C28H29F2N3O

• Molecular Weight:

  461.55

• Precautions:

  P264-P270-P280-P330-P405-P501

• References & Citations:

  [1]Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256 (2) :141-7.|[2]Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9 (8) :3853-3866. eCollection 2017.|[3]Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117 (12) : 3421-3429.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• Clinical Information:

  Launched

• CAS Number:

  2062-78-4