Quinaprilat-d5

CAT: 0804-HY-127026SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-127026SSize:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Quinaprilat-d5 is a deuterium-labeled Quinaprilat (HY-127026) . Quinaprilat is a nonsulfhydryl ACE inhibitor, the active diacid metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits bradykinin degradation. Quinaprilat primarily acts as a vasodilator, decreasing total peripheral and renal vascular resistance[1].
CAS Number
[1279034-23-9]
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
C([C@@H](N[C@@H](CCC1=C(C(=C(C(=C1[2H])[2H])[2H])[2H])[2H])C(O)=O)C)(=O)N2[C@H](C(O)=O)CC=3C(C2)=CC=CC3
Molecular Formula
C23H21D5N2O5
Molecular Weight
415.49
References & Citations
[1]Kieback AG, et al. Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. Expert Opin Drug Metab Toxicol. 2009;5 (10) :1337-1347. |[2]Haodan Yuan, et al. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. J Pharmacol Exp Ther. 2009 Jul;330 (1) :191-7. doi: 10.1124/jpet.108.149476. Epub 2009 Apr 6.|[3]Sinisa Stanisavljevic, et al. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. J Pharmacol Exp Ther. 2006 Mar;316 (3) :1153-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-127026-01Quinaprilat
HY-127026AQuinaprilat (hydrate)
HY-127026BQuinaprilat (hydrochloride)
HY-127026RQuinaprilat (Standard)
HY-B0477ASQuinapril-d5
HY-B0477AS1-01Quinapril-d5 (hydrochloride)
HY-W717221Medetomidine-d5 (d5-Major)
HY-151913S-01Sebuthylazine-d5 (ethyl-d5)
HY-133171AS-01(S) -Norfluoxetine-d5 (phenyl-d5)
HY-151910S1(±) -Fluoxetine-d5 Oxalate (phenyl-d5)

Alternative Products

CatalogName
TRC-Q670012-50MGQuinaprilat-d5
MBS5756623Quinaprilat
MF-0148068-01Quinaprilat hydrochloride
MF-0109795-01Quinaprilat hydrate
463364-01Quinaprilat-d4 Hydrate
TRC-N144200-25MGN-Nitroso Quinaprilat
sc-476927Quinaprilat-d4 Monohydrate
TRC-S211421-0.5MGSebuthylazine-d5 (ethyl-d5)
TRC-L469581-5MGLoratadine-d5 (ethyl-d5)
TRC-F279491-5MGFenuron-d5 (phenyl-d5)

Popular Products