Aminooxy-PEG4-azide

CAT: 0804-HY-126950-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-126950-01Size:25 mg

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Description

Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

2100306-61-2

UNSPSC

12352211

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aminooxy-peg4-azide.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCOCCOCCOCCON

Molecular Formula

C10H22N4O5

Molecular Weight

278.31

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

Aminooxy-PEG4-azide

CAS Number	2100306-61-2
PubChem CID	126480410
IUPAC Name	O-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]hydroxylamine
Molecular Formula	C10H22N4O5
Molecular Weight	278.31
XLogP	-0.4
Topological Polar Surface Area	86.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	15
Heavy Atom Count	19
Formal Charge	0
Complexity	226

SMILES

C(COCCOCCOCCOCCON)N=[N+]=[N-]

InChI

InChI=1S/C10H22N4O5/c11-14-13-1-2-15-3-4-16-5-6-17-7-8-18-9-10-19-12/h1-10,12H2

InChIKey

LGQSVZJZFYJANR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2100306-61-2

CID: 126480410

Formula: C10H22N4O5

MW: 278.31

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	278.31
XLogP3	-0.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	15
Exact Mass	278.15901982
Monoisotopic Mass	278.15901982
Topological Polar Surface Area	86.5 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	226
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-126949-01	Aminooxy-PEG3-azide
HY-126948-01	Aminooxy-PEG1-azide
HY-130507-01	Aminooxy-PEG5-azide
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Alternative Products

Catalog	Name
MBS5768424	Aminooxy-PEG4-azide
MBS5768736	Boc-Aminooxy-PEG4-azide
571948	t-Boc-Aminooxy-PEG4-azide
T14620-01	Bis-aminooxy-PEG4
571908	Aminooxy-PEG4-acid
MBS5768427	Aminooxy-PEG4-propargyl
571911	Aminooxy-PEG4-alcohol
571924	Aminooxy-PEG4-CH2CO2tBu
BIPG1968-01	Aminooxy-PEG4-MMAF
T18534-01	PEG4-aminooxy-MMAF

Aminooxy-PEG4-azide

Chemical Information

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