Aminooxy-PEG3-azide

CAT: 0804-HY-126949-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-126949-01Size:5 mg

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Description

Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

1306615-51-9

UNSPSC

12352203

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aminooxy-peg3-azide.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

NOCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C8H18N4O4

Molecular Weight

234.25

References & Citations

[1]Chanhyuk KIM, et al. Optimized chimeric receptor t cell switches and uses thereof. WO2016168766A1.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Non-cleavable Linker; PEG Linkers

Chemical Information

Aminooxy-PEG3-azide

CAS Number	1306615-51-9
PubChem CID	57517112
IUPAC Name	O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]hydroxylamine
Molecular Formula	C8H18N4O4
Molecular Weight	234.25
XLogP	-0.2
Topological Polar Surface Area	77.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	12
Heavy Atom Count	16
Formal Charge	0
Complexity	187

SMILES

C(COCCOCCOCCON)N=[N+]=[N-]

InChI

InChI=1S/C8H18N4O4/c9-12-11-1-2-13-3-4-14-5-6-15-7-8-16-10/h1-8,10H2

InChIKey

WSRXFPCTWIFEOF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1306615-51-9

CID: 57517112

Formula: C8H18N4O4

MW: 234.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	234.25
XLogP3	-0.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	12
Exact Mass	234.13280507
Monoisotopic Mass	234.13280507
Topological Polar Surface Area	77.3 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	187
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-140398-01	M-PEG3-Aminooxy
HY-140057	Aminooxy-PEG3-propargyl
HY-140005-01	Aminooxy-PEG3-acid
HY-126950-01	Aminooxy-PEG4-azide
HY-130507-01	Aminooxy-PEG5-azide
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T15852-01	m-PEG3-Aminooxy
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Aminooxy-PEG3-azide

Chemical Information

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