Ortho-hydroxy atorvastatin-d5 (calcium)

Ortho-hydroxy atorvastatin-d5 (calcium)

• CAS Number: 265989-47-7
• UNSPSC Description: Ortho-hydroxy atorvastatin-d5 calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577)[1]. Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589)[2].
• Target Antigen: Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Others
• Field of Research: Others
• Solubility: 10 mM in DMSO
• Smiles: OC1=C(NC(C2=C(N(C(C3=CC=C(F)C=C3)=C2C4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])CC[C@H](C[C@H](CC(O)=O)O)O)C(C)C)=O)C=CC=C1.[Ca].[1/2]
• Molecular Weight: 599.71
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Zhou Y, et al. Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous determination of amlodipine, atorvastatin and its metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin in human plasma and its application in a bioequivalence study. J Pharm Biomed Anal. 2013 Sep;83:101-7.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported