Coumarin-SAHA

• Description :

  Coumarin-SAHA is a fluorescent probe for determining the binding affinities (kd) and the dissociation off-rates (koff) of the HDAC8-inhibitor complexes[1].

• UNSPSC :

  12352005

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/coumarin-saha.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NO)CCCCCCC(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O

• Molecular Formula :

  C18H22N2O5

• Molecular Weight :

  346.38

• References & Citations :

  [1]Raushan K Singh, et al. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. Anal Biochem

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC8

• CAS Number :

  [1260635-77-5]