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GS-443902

CAT: 0804-HY-126303Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126303Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].
CAS Number
1355149-45-9
Product Name Alternative
GS-441524 triphosphate; Remdesivir metabolite
UNSPSC
12352005
Target
DNA/RNA Synthesis; Drug Metabolite; HCV; RSV; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-443902.html
Purity
99.87
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=P(OP(O)(O)=O)(O)OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O)=O
Molecular Formula
C12H16N5O13P3
Molecular Weight
531.20
References & Citations
[1]Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60 (5) :1648-1661.|[2]Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2705-7.|[3]Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531 (7594) :381-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Acta Pharm Sin B. 2021 Jun;11 (6) :1607-1616.|Cell. 2022 Nov 10;185 (23) :4347-4360.e17.|Chem Biol Interact. 2021 Jul 1:343:109480.|Curr Res Pharmacol Drug Discov. 2021:2:100045.|EMBO J. 2025 Jan;44 (2) :563-586.|Int J Mol Sci. 2022 Jul 27;23 (15) :8302.|J Med Chem. 2025 Jun 26;68 (12) :12414-12433.|Research Square Preprint. 2022 May.|bioRxiv. 2021 Jul 21:2021.07.21.453274. |J Control Release. 2025 Sep 18:387:114245.|J Med Chem. 2024 May 9;67 (9) :7470-7486.|Nat Commun. 2021 Oct 4;12 (1) :5811.|Sci Rep. 2022 Nov 2;12 (1) :18506.

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