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GS 283

CAT: 0804-HY-114743Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114743Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GS 283 is a compound with calcium antagonist and weak histamine and muscarinic receptor blocking activity, with activity in modulating contraction of guinea pig and rat tracheal smooth muscle. GS 283 inhibits contractions induced by carbachol, histamine (guinea pig only), and high H+ in guinea pig and rat tracheal smooth muscle, inhibits Ca2+-induced contractions in guinea pig tracheal smooth muscle, and at high concentrations completely abolishes contractions induced by carbachol in Ca2+-free medium.
CAS Number
149440-36-8
UNSPSC
12352005
Target
CRAC Channel; Histamine Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gs-283.html
Smiles
OC1=C(N=C(C2=C1C=C(C(O)=C2)O)CC3=CC=C(C=C3)OC)O
Molecular Formula
C17H15NO5
Molecular Weight
313.30
References & Citations
[1]Pharmacological characterization of effects of verapamil and GS 283 on isolated guinea pig and rat trachealis
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported