NOC-5

• Description :

  NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors. NOC-5 is able to increase intracellular XIAP and Aven levels, potentially leading to the inhibition of caspase-9 activity following increased mitochondrial permeability[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H242

• Target :

  IAP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/noc-5.html

• Purity :

  98.50

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(N(CCCN)N(N=O)O)C

• Molecular Formula :

  C6H16N4O2

• Molecular Weight :

  176.22

• Precautions :

  H242

• References & Citations :

  [1]Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.|[2]Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38 (7) :799-802.|[3]Starikova EG, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38 (7) :799-802.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [146724-82-5]