Brevetoxin-3

CAT: 0804-HY-12545Size: 100 µgDry Ice: NoHazardous: No
CAT#:0804-HY-12545Size:100 µg
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Description
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) [1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].
CAS Number
[85079-48-7]
Product Name Alternative
PbTx-3
UNSPSC
12352005
Hazard Statement
H300, H410
Target
Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/brevetoxin-3.html
Purity
95.0
Solubility
Ethanol : 10 mg/mL (ultrasonic; warming)
Smiles
C[C@@]12[C@](C[C@@]3([H])[C@@](C)(CC[C@@]4([H])[C@]([C@@H](C[C@@]5([H])[C@](C[C@@]6(C)[C@](C[C@@](O7)([H])[C@](C(C)=CC7=O)([H])O6)([H])O5)([H])O4)C)([H])O3)O2)([H])O[C@]8(C)[C@@](O[C@]9([H])[C@@](O[C@]%10([H])[C@@](O[C@]%11(C)[C@@](O[C@H](CC(CO)=C)C[C@@H]%11O)([H])C%10)([H])C9)([H])/C=C\C8)([H])C1
Molecular Formula
C50H72O14
Molecular Weight
897.10
Precautions
H300, H410
References & Citations
[1]Jeglitsch G, et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284 (2) :516-25.|[2]Zaias J, et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23 (4) :205-11.|[3]Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon. 2006 Dec 15;48 (8) :1018-26. Epub 2006 Aug 18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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