Brevetoxin B

CAT: 0804-HY-12546Size: 100 µgDry Ice: NoHazardous: No
CAT#:0804-HY-12546Size:100 µg
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Description
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.
CAS Number
[79580-28-2]
Product Name Alternative
Brevetoxin-2; PbTx-2
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/brevetoxin-b.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
C[C@@]1(O[C@](C)(CC[C@@](O[C@@](C[C@](C)(O[C@@](C(C)=CC2=O)([H])[C@](O2)([H])C3)[C@]3([H])O4)([H])[C@]4([H])C5)([H])[C@]([C@@H]5C)([H])O6)[C@]6([H])C7)[C@]7([H])O[C@]8(C)[C@@](O[C@](C[C@](O[C@@](C)([C@H]9O)[C@@](O[C@H](CC(C=O)=C)C9)([H])C%10)([H])[C@@]%10([H])O%11)([H])[C@@]%11([H])/C=C\C8)([H])C1
Molecular Formula
C50H70O14
Molecular Weight
895.08
Precautions
H300+H310+H330
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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