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SHP844

CAT: 0804-HY-125260Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125260Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP844 is a SHP2 inhibitor with the IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival[1].
CAS Number
2222280-82-0
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp844.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H]1N(C(C2=CC=C(CN3C4=NN=C(C5=CC=CC(OC)=C5O)N4C6=C(C=CC=C6)C3=O)C(Cl)=C2)=O)CCC1
Molecular Formula
C29H24ClN5O6
Molecular Weight
573.98
References & Citations
[1]Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13 (3) :647-656.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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