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SHP244

CAT: 0804-HY-115527Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115527Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers[1].
CAS Number
902891-37-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
SHP2
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C2=C(N3C(C4=C(O)C(OC)=CC=C4)=NN=C3N1CC5=C(Cl)C=CC=C5)C=CC=C2
Molecular Formula
C23H17ClN4O3
Molecular Weight
432.86
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Lu H, et al. Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR. Oncotarget. 2020 Jan 21;11 (3) :265-281.|[2]Song Y, et al. Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery. Medicinal Research Reviews. 2022 Sep;42 (5) :1781-821.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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