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Oltipraz

CAT: 0804-HY-12519-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12519-01Size:5 mg
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Description
Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
CAS Number
64224-21-1
Product Name Alternative
RP 35972; NSC 347901
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase; HIV; Keap1-Nrf2; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Oltipraz.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 6 mg/mL (ultrasonic; warming)
Smiles
S=C1SSC(C2=NC=CN=C2)=C1C
Molecular Formula
C8H6N2S3
Molecular Weight
226.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8 (10) :2791-802.|[2]Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98 (6) :3410-5.|[3]Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234 (2) :73-87.|[4]Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49 (2) :324-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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CatalogName
B5958-5.1Oltipraz

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