Oltipraz

• Description :

  Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

• Product Name Alternative :

  RP 35972; NSC 347901

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HIF/HIF Prolyl-Hydroxylase; HIV; Keap1-Nrf2; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Oltipraz.html

• Concentration :

  10mM

• Purity :

  99.87

• Solubility :

  DMSO : 6 mg/mL (ultrasonic; warming)

• Smiles :

  S=C1SSC(C2=NC=CN=C2)=C1C

• Molecular Formula :

  C8H6N2S3

• Molecular Weight :

  226.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8 (10) :2791-802.|[2]Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98 (6) :3410-5.|[3]Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234 (2) :73-87.|[4]Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49 (2) :324-33.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• CAS Number :

  [64224-21-1]