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Oltipraz (Standard)

CAT: 0804-HY-12519R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12519R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oltipraz (Standard) is the analytical standard of Oltipraz. This product is intended for research and analytical applications. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
CAS Number
64224-21-1
UNSPSC
12352100
Target
HIF/HIF Prolyl-Hydroxylase; HIV; Keap1-Nrf2; Parasite; Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer
Smiles
S=C1SSC(C2=NC=CN=C2)=C1C
Molecular Formula
C8H6N2S3
Molecular Weight
226.34
References & Citations
[1]Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8 (10) :2791-802.|[2]Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98 (6) :3410-5.|[3]Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234 (2) :73-87.|[4]Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49 (2) :324-33.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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