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Bempedoic acid-d5

CAT: 0804-HY-12357S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12357S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bempedoic acid-d5 is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].
CAS Number
2408131-71-3
Product Name Alternative
ETC-1002-d5; ESP-55016-d5
UNSPSC
12352211
Target
AMPK; ATP Citrate Lyase
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
OC(C(C)(C)CCCCC([2H])([2H])C(O)([2H])C([2H])([2H])CCCCC(C)(C)C(O)=O)=O
Molecular Formula
C19H31D5O5
Molecular Weight
349.52
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54 (1) :134-51.|[3]Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug54 (8) :2095-108.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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