Products for Research Use Only
RegisterLogin

Ethylmalonic acid-d5

CAT: 0804-HY-34740S1-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-34740S1-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ethylmalonic acid-d5 is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation[1][2][3][4][5].
CAS Number
66311-22-6
UNSPSC
12352211
Target
Isotope-Labeled Compounds; Mitochondrial Metabolism
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease; Neurological Disease
Purity
98.09
Solubility
10 mM in DMSO|DMSO : 250mg/mL (ultrasonic)
Smiles
O=C(O)C(C([2H])([2H])C([2H])([2H])[2H])C(O)=O
Molecular Formula
C5H3D5O4
Molecular Weight
137.15
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26 (2) :168-78.|[3]Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28 (5) :771-7.|[4]Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35 (2) :298-305.|[5]Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10 (5) :e0126606.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-34740-01Ethylmalonic acid
HY-34740R-01Ethylmalonic acid (Standard)
HY-34740S-01Ethylmalonic acid-d3
HY-W653947Glycoursodeoxycholic acid-d5
HY-B1899STaurodeoxycholic acid-d5
HY-108538Ethacrynic acid D5
HY-N1423S1Glycocholic acid-d5
HY-113099SIndolelactic acid-d5
HY-Y0839S-01Levulinic acid-d5
HY-N2041S6-01Myristic acid-d5

Alternative Products

CatalogName
449809-01Ethylmalonic Acid
TRC-D477942-25MG(1,3-Dimethylbutyl)ethylmalonic Acid-d5 Diethyl Ester
E12040-01Ethylmalonic acid 97%
411125-01(1,3-Dimethylbutyl) ethylmalonic Acid-d5 Diethyl Ester
A12243-500Ethylmalonic acid 500mg
A12243-1000Ethylmalonic acid 1000mg
D2643Ethylmalonic Acid) Human ELISA Kit
A12243-10mM-DEthylmalonic acid 10mM * 1mL in DMSO
MBS9310073-01Human ethylmalonic acid ELISA Kit
411124-01(1,3-Dimethylbutyl) ethylmalonic Acid Diethyl Ester

Popular Products