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Samelisant (free base)

CAT: 0804-HY-122608Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122608Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Samelisant (SUVN-G3031) free base is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant free base has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R; Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant free base can be used for the research of sleep-related disorders[1].
CAS Number
1394808-82-2
Product Name Alternative
SUVN-G3031 (free base)
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/samelisant-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(OC2CCN(C3CCC3)CC2)C=C1)CN4CCOCC4
Molecular Formula
C21H31N3O3
Molecular Weight
373.49
References & Citations
[1]Nirogi R, et al. Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation. Psychopharmacology (Berl) . 2021 Jun;238 (6) :1495-1511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
H3 Receptor

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