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Tr-PEG5-OH

CAT: 0804-HY-120845-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120845-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
CAS Number
141282-24-8
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tr-peg5-oh.html
Solubility
10 mM in DMSO
Smiles
OCCOCCOCCOCCOCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C29H36O6
Molecular Weight
480.59
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Branderhorst HM, et al. Strong inhibition of cholera toxin binding by galactose dendrimers. Chem Commun (Camb) . 2007 Dec 21; (47) :5043-5.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

Chemical Information

Tr-PEG6
CAS Number141282-24-8
PubChem CID54298879
IUPAC Name2-[2-[2-[2-(2-trityloxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
Molecular FormulaC29H36O6
Molecular Weight480.6
XLogP3.5
Topological Polar Surface Area66.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count18
Heavy Atom Count35
Formal Charge0
Complexity452
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCCOCCOCCOCCOCCO
InChI
InChI=1S/C29H36O6/c30-16-17-31-18-19-32-20-21-33-22-23-34-24-25-35-29(26-10-4-1-5-11-26,27-12-6-2-7-13-27)28-14-8-3-9-15-28/h1-15,30H,16-25H2
InChIKey
SCTIZOCQZVDVRN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tr-PEG6
CAS: 141282-24-8
CID: 54298879
Formula: C29H36O6
MW: 480.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight480.6
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count18
Exact Mass480.25118886
Monoisotopic Mass480.25118886
Topological Polar Surface Area66.4 Ų
Heavy Atom Count35
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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