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Tr-PEG2-OH

CAT: 0804-HY-114995-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-114995-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
CAS Number
[105589-77-3]
Product Name Alternative
6-Hydroxybentazone
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tr-peg2-oh.html
Purity
99.84
Solubility
10 mM in DMSO
Smiles
OCCOCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C23H24O3
Molecular Weight
348.44
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.|[2]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

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