RegisterLogin

CFI-400437

CAT: 0804-HY-120279ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120279ASize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM) [1].
CAS Number
[1169211-37-3]
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfi-400437.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(OC)C=C2)/C1=C\C3=CC4=C(C=C3)C(/C=C/C5=CC=C(N6CCN(C)CC6)N=C5)=NN4
Molecular Formula
C29H28N6O2
Molecular Weight
492.57
References & Citations
[1]Radoslaw Laufer, et al. The discovery of PLK4 inhibitors: (E) -3- ((1H-Indazol-6-yl) methylene) indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013 Aug 8;56 (15) :6069-87.|[2]Amreena Suri, et al. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer. Int J Mol Sci. 2019 Apr 29;20 (9) :2112.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-123675CFI-400936
HY-116190CFI-401870
HY-120032CFI-401980
HY-P88426CFI Antibody (YA8110, Mouse)
HY-RS20677Cfi Mouse Pre-designed siRNA Set A
HY-RS02567CFI Human Pre-designed siRNA Set A
HY-RS27188Cfi Rat Pre-designed siRNA Set A
HY-105188AONO-4007
HY-118575DR-4004

Alternative Products

CatalogName
GW2058-10mgCFI-400437
MBS3613099-01CFI-400437 dihydrochloride
MBS3846983-01CFI-400437 HCl
A22463-10CFI-400437 HCl 10mg
C07150(1E) -CFI-400437 dihydrochloride
A22463-1CFI-400437 HCl 1mg
A22463-50CFI-400437 HCl 50mg
A22463-5CFI-400437 HCl 5mg
A22463-25CFI-400437 HCl 25mg
A22463-100CFI-400437 HCl 100mg

Popular Products