DH-376

• Description :

  DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice[1]. DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• CAS Number :

  [1848233-57-7]

• UNSPSC :

  12352005

• Target :

  DAGL; MAGL

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/dh-376.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1N=CC(C(C2=CC=C(F)C=C2)(C3=CC=C(F)C=C3)O)=N1)N4[C@@H](CC5=CC=CC=C5)CC[C@@H](OCC#C)C4

• Molecular Formula :

  C31H28F2N4O3

• Molecular Weight :

  542.58

• References & Citations :

  [1]Deng H, et, al. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem. 2017 Jan 12;60 (1) :428-440.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported