AE-3763

• Description :

  AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

• UNSPSC :

  12352005

• Target :

  Elastase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/AE-3763.html

• Purity :

  99.82

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CN1CCN(CC(N[C@H](C(N2[C@H](C(N[C@@H](C(C)C)C(C(F)(F)F)=O)=O)CCC2)=O)C(C)C)=O)C1=O

• Molecular Formula :

  C23H34F3N5O7

• Molecular Weight :

  549.54

• References & Citations :

  [1]Inoue Y, et al. Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem. 2009 Nov 1;17 (21) :7477-86.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [291778-77-3]