AE-3763

• Description:

  AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

• UNSPSC:

  12352005

• Target:

  Elastase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/AE-3763.html

• Purity:

  99.82

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  O=C (O) CN1CCN (CC (N[C@H] (C (N2[C@H] (C (N[C@@H] (C (C) C) C (C (F) (F) F) =O) =O) CCC2) =O) C (C) C) =O) C1=O

• Molecular Formula:

  C23H34F3N5O7

• Molecular Weight:

  549.54

• References & Citations:

  [1]Inoue Y, et al. Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem. 2009 Nov 1;17 (21) :7477-86.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  291778-77-3