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DH-18

CAT: 0804-HY-168605Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168605Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DH-18 is a matrix metalloproteinase-2 (MMP-2) inhibitor with the IC50 values of 139.45 nM, 518.11 nM and 833.34 nM for MMP-2, MMP-9 and MMP-8, respectively. DH-18 induces cell apoptosis and arrests cell cycle in the G0/G1 phase. DH-18 inhibits cell growth and can be used for study of chronic myeloid leukemia[1].
UNSPSC
12352211
Target
Apoptosis; MMP
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dh-18.html
Smiles
O=C(NCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)CCC(C(NO)=O)NS(=O)(C2=CC=C(C=C2)C3=CC=CC=C3)=O
Molecular Formula
C26H23F6N3O5S
Molecular Weight
603.53
References & Citations
[1]Baidya SK, et al. Biphenylsulfonamides as effective MMP-2 inhibitors with promising antileukemic efficacy: Synthesis, in vitro biological evaluation, molecular docking, and MD simulation analysis. Drug Dev Res. 2024 Sep;85 (6) :e22255.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-8; MMP-9

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