Fluphenazine (dimaleate)

CAT: 0804-HY-119980ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-119980ASize:1 Each
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Description
Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].
CAS Number
[3093-66-1]
UNSPSC
12352005
Hazard Statement
H302-H312-H315-H319-H332-H335
Target
Dopamine Receptor; SARS-CoV; Sodium Channel
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/fluphenazine-dimaleate.html
Solubility
10 mM in DMSO
Smiles
OCCN(CC1)CCN1CCCN2C3=CC(C(F)(F)F)=CC=C3SC4=CC=CC=C42.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O
Molecular Formula
C30H34F3N3O9S
Molecular Weight
669.67
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006 Aug 23;1106 (1) :72-81.|[2]Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec;25 (10) :1123-1140.|[3]Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan.|[4]Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21;238 (21) :2291-2.|[5]Abdel-Hamid HA, et al. Teratogenic effect of diphenylhydantoin and/or fluphenazine in mice. J Appl Toxicol. 1996 May-Jun;16 (3) :221-5.|[6]Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312 (3) :225-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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