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Fluphenazine-d8

CAT: 0804-HY-119980SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119980SSize:1 mg
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Description
Fluphenazine-d8 is the deuterium labeled Fluphenazine. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][5][6].
CAS Number
1323633-98-2
UNSPSC
12352005
Target
Dopamine Receptor; Isotope-Labeled Compounds; SARS-CoV; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
COVID-19-anti-virus
Field of Research
Others
Purity
99.12
Solubility
10 mM in DMSO
Smiles
OCCN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1CCCN2C3=CC(C(F)(F)F)=CC=C3SC4=CC=CC=C42
Molecular Formula
C22H18D8F3N3OS
Molecular Weight
445.57
References & Citations
[1]Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006;1106 (1) :72-81.|[2]Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec;25 (10) :1123-1140.|[3]Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan.|[4]Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21;238 (21) :2291-2.|[5]Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312 (3) :225-7.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[7]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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