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1'-Hydroxymidazolam-d4

CAT: 0804-HY-118645SSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-118645SSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1781843-10-4
UNSPSC Description
1'-Hydroxymidazolam-d4 is the deuterium labeled 1'-Hydroxymidazolam. 1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam[1][2].
Target Antigen
Drug Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.12
Solubility
10 mM in DMSO
Smiles
OCC1=NC=C2CN=C(C3=C(C([2H])=C([2H])C([2H])=C3[2H])F)C4=CC(Cl)=CC=C4N12
Molecular Weight
345.79
References & Citations
[1]Hasegawa T, et, al. Increase in the systemic exposure of primary metabolites of Midazolam in rat arising from CYP inhibition or hepatic dysfunction. Drug Metab Pharmacokinet. 2017 Feb; 32(1): 69-76. |[2]Balk M, et, al. Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Sci Rep. 2017 Jun 14; 7(1): 3503. |[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Clinical Information
No Development Reported

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