LY 292728

• Description :

  LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a Ki of 0.47 nM and binds to guinea pig lung membranes with a Ki of 0.04 nM[1].

• CAS Number :

  [153034-77-6]

• UNSPSC :

  12352005

• Target :

  Leukotriene Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ly-292728.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)C1=CC2=C(C=C1)OC3=C(C=CC(OCCCOC4=C(C=C(C(O)=C4)C5=CC=C(C=C5)F)CC)=C3CCC(O)=O)C2=O

• Molecular Formula :

  C34H29FO9

• Molecular Weight :

  600.59

• References & Citations :

  [1]Sawyer JS, et al. Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36 (24) :3982-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported