Anticancer agent 39

• UNSPSC Description :

  Anticancer agent 39 (compound B12), a fluorescent derivative of Jiyuan Oridonin A (JOA), induces the collapse of mitochondrial membrane potential (MMP)and thus induced apoptosis.Anticancer agent 39 inhibits cell cloning and migration.Anticancer agent 39 exhibits promising anti-proliferative activity against HGC-27 cells with IC50 value of 0.39 μM[1].

• Target Antigen :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-39.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@@]([C@]1([H])C2=C)([H])[C@@]3(C2=O)[C@]([C@H](C1)O)([H])C4(CCCC(C)5C)[C@]5([H])C[C@@]3([H])O[C@H]4OCCCC(N=N6)=CN6CCOCCOCCOCCN(C7=O)C(C8=CC=C(N9CCCCC9)C%10=C8C7=CC=C%10)=O

• Molecular Weight :

  896.08

• References & Citations :

  [1]Chen Zhou, et al. Synthesis, biological evaluation and cellular localization study of fluorescent derivatives of Jiyuan Oridonin A. Eur J Med Chem. 2022 Feb 5;229:114048.

• Shipping Conditions :

  Room temperature

• Clinical Information :

  No Development Reported

• CAS Number :

  [9007-83-4]