Urease-IN-2

• UNSPSC Description:

  Urease-IN-2 (compound 8g) is a non-competitive urease inhibitor with an IC50 of 0.94 μM and a Ki of 1.6 μM. Urease-IN-2 inhibits the Jack bean urease (JBU) in a non-competitive manner[1].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/urease-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N(C1=CC=CC=C1)C(CSC2=NN=C(S2)C3=CC=C(O3)[N+]([O-])=O)=O)C4=CC=CS4)NC5CCCCC5

• Molecular Weight:

  583.70

• References & Citations:

  [1]Mehdi Asadi, et al. Synthesis and in vitro urease inhibitory activity of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-(phenylamino)acetamides, in silico and kinetic studies. Bioorg Chem. 2022 Jan 17;120:105592.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported