DENV-IN-4

• Description:

  DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9) . DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/denv-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@@] (CC2=CC=CC=C23) ([H]) N3[C@] (C4=CC=C (C=C4) O[Si] (C) (C) C (C) (C) C) ([H]) N1NC5=CC=C (C=C5) [N+] ([O-]) =O

• Molecular Formula:

  C28H32N4O4Si

• Molecular Weight:

  516.66

• References & Citations:

  [1]Qian W, et al. Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection [published online ahead of print, 2022 Jan 24]. Bioorg Chem. 2022;120:105639.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2762302-75-8