DENV-IN-2

• Description:

  DENV-IN-2 is a potent dengue viral replication inhibitor extracted from patent WO2018215315A1, compound 6AB, has an EC50 of 0.016 nM. DENV-IN-2 shows high potent activity against all four serotypes of the Dengue virus with EC50s ranging from 0.013 to 0.029 nM[1].

• UNSPSC:

  12352005

• Target:

  Dengue Virus; DNA/RNA Synthesis; Flavivirus

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/denv-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1[C@H](COC2=CC(OC)=CC(N[C@@H](C3=CC=C(Cl)C=C3)C(N4CCC5=C4C=C(OC(F)(F)F)C=C5)=O)=C2)C1)O

• Molecular Formula:

  C29H26ClF3N2O6

• Molecular Weight:

  590.97

• References & Citations:

  [1]Jean-François BONFANTI, et al.Substituted indoline derivatives as dengue viral replication inhibitors. WO2018215315A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2253675-62-4